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Article

DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves.

PloS one - 1 Jan 2015

Safra Noa, Hayward Louisa J, Aguilar Miriam, Sacks Benjamin N, Westropp Jodi L, Mohr F Charles, Mellersh Cathryn S, Bannasch Danika L

Abstract excerpt

The aim of this study was to investigate the frequency of regional DNA variants upstream to the translation initiation site of the canine Cyclooxygenase-2 (Cox-2) gene in healthy dogs. Cox-2 plays a role in various disease conditions such as acute and chronic inflammation, osteoarthritis and malignancy. A role for Cox-2 DNA variants in genetic predisposition to canine renal dysplasia has been proposed and dog...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26244515
DOI: 10.1371/journal.pone.0133127
PMCID: PMC4526539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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