Article
New mutations associated with resistance not detected following zidovudine monotherapy in pregnancy when used in accordance with British HIV Association guidelines.
HIV medicine - 1 Aug 2008
Read P, Costelloe S, Mullen J, O'Shea S, Lyons F, Hay P, Welch J, Larbalestier N, Taylor Gp, de Ruiter A
Abstract excerpt
OBJECTIVES: To determine whether mutations conferring drug resistance are detectable after zidovudine monotherapy (ZDVm) in pregnancy, using both standard genotyping and more sensitive cloning assays. METHODS: Post-delivery samples from women meeting the British HIV Association guidelines criteria for the use of ZDVm in the prevention of mother-to-child transmission (MTCT) and who received ZDVm were analysed...
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