Article
Functional genetic variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians.
Future oncology (London, England) - 1 Jan 2015
Sodhi Kushaldeep Kaur, Bahl Charu, Singh Navneet, Behera Digamber, Sharma Siddharth
Abstract excerpt
OBJECTIVE: To find the association of two pre-miRNA polymorphisms with risk of lung cancer in North Indians. MATERIALS & METHODS: Genotyping of 250 cases and 255 controls for miR-146a and miR-196a2 using PCR-RFLP. RESULTS: Heterozygous subjects showed a risk toward lung cancer (LC), especially for adenocarcinoma (OR: 1.82; 95% CI: 1.04-3.20; p = 0.03) in miR-146a gene. TT genotype for miR-196a2 gene also showed...
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