Article
Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.
Protein science : a publication of the Protein Society - 1 Oct 2015
Milkovic Nicole M, Catazaro Jonathan, Lin Jiusheng, Halouska Steven, Kizziah James L, Basiaga Sara, Cerny Ronald L, Powers Robert, Wilson Mark A
Abstract excerpt
Various missense mutations in the cytoprotective protein DJ-1 cause rare forms of inherited parkinsonism. One mutation, M26I, diminishes DJ-1 protein levels in the cell but does not result in large changes in the three-dimensional structure or thermal stability of the protein. Therefore, the molecular defect that results in loss of M26I DJ-1 protective function is unclear. Using NMR spectroscopy near...
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