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Borrelia burgdorferi Binds Fibronectin through a Tandem β-Zipper, a Common Mechanism of Fibronectin Binding in Staphylococci, Streptococci, and Spirochetes

1 Mar 2005

Abstract excerpt

BBK32 is a fibronectin-binding protein from the Lyme disease-causing spirochete Borrelia burgdorferi. In this study, we show that BBK32 shares sequence similarity with fibronectin module-binding motifs previously identified in proteins from Streptococcus pyogenes and Staphylococcus aureus. Nuclear magnetic resonance spectroscopy and isothermal titration calorimetry are used to confirm the binding sites of BBK32...

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PMID: 15737988
DOI: 10.1074/jbc.m501731200

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