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Article

Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfecta.

BMC evolutionary biology - 30 Jul 2015

Delsuc Frédéric, Gasse Barbara, Sire Jean-Yves

Abstract excerpt

BACKGROUND: Ameloblastin (AMBN) is a phosphorylated, proline/glutamine-rich protein secreted during enamel formation. Previous studies have revealed that this enamel matrix protein was present early in vertebrate evolution and certainly plays important roles during enamel formation although its precise functions remain unclear. We performed evolutionary analyses of AMBN in order to (i) identify residues and...

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Source

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Identifiers

PMID: 26223266
DOI: 10.1186/s12862-015-0431-0
PMCID: PMC4518657

Genes

AMBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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