Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-α and IL-6 in Behcet's Disease.

doi:10.1371/journal.pone.0134632

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Article

Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-α and IL-6 in Behcet's Disease.

PloS one - 1 Jan 2015

Jiang Zhengxuan, Hennein Lauren, Tao Yulin, Tao Liming

Abstract excerpt

PURPOSE: Recent studies identified an association between Behcet's disease (BD) and the IL-23R gene polymorphism (rs17375018) in different populations. This study examined whether this IL-23R gene polymorphism is associated with enhanced inflammatory responses. METHODS: We recruited 27 BD patients and 32 controls with three genotypes. Peripheral blood mononuclear cells (PBMCs) were seeded with or without anti-CD3...

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PMID: 26222305
DOI: 10.1371/journal.pone.0134632
PMCID: PMC4519128

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