Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to Behçet's disease in the Iranian population.

doi:10.1684/ecn.2020.0458

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Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to Behçet's disease in the Iranian population.

European cytokine network - 1 Dec 2020

Gholijani Nasser, Daryabor Gholamreza, Kalantar Kurosh, Yazdani Mohammad-Reza, Shenavandeh Saeedeh, Zahed Maryam, Jafarpour Zahra, Malekmakan Mohammad-Reza, Amirghofran Zahra

Abstract excerpt

Behcet's disease (BD) is a systemic vasculitis, characterized by recurrent oral aphthous, genital ulcers, ocular lesions, and other organ involvement. Interleukin (IL)-27 with its pro- and anti-inflammatory effects might be an important effective cytokine in this disease. The aim of this study was to investigate the association of IL-27 serum concentration and a single-nucleotide polymorphism (SNP) rs153109 (-964...

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PMID: 33648922
DOI: 10.1684/ecn.2020.0458

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