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Dating the origin of hepatitis B virus reveals higher substitution rate and adaptation on the branch leading to F/H genotypes.

Molecular phylogenetics and evolution - 1 Dec 2015

Paraskevis Dimitrios, Angelis Konstantinos, Magiorkinis Gkikas, Kostaki Evangelia, Ho Simon Y W, Hatzakis Angelos

Abstract excerpt

The evolution of hepatitis B virus (HBV), particularly its origins and evolutionary timescale, has been the subject of debate. Three major scenarios have been proposed, variously placing the origin of HBV in humans and great apes from some million years to only a few thousand years ago (ka). To compare these scenarios, we analyzed 105 full-length HBV genome sequences from all major genotypes sampled globally. We...

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Identifiers

PMID: 26220838
DOI: 10.1016/j.ympev.2015.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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