Article
Origin of HBV and its arrival in the Americas--the importance of natural selection on time estimates.
Antiviral therapy - 1 Jan 2013
Godoy Bibiane A, Alvarado-Mora Mónica V, Gomes-Gouvêa Michele S, Pinho João R Rebello, Fagundes Nelson
Abstract excerpt
BACKGROUND: The strong geographic structure shown by the global pattern of HBV lineages suggests an ancient origin for this virus; however, estimates based on the molecular clock suggest a very recent origin for the Native American genotypes F and H. In this study, we contribute to this debate by estimating the divergence times of genotypes F and H and by discussing how evolutionary rates estimated from recent...
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