Article
Decreasing relapse in colorectal cancer patients treated with cetuximab by using the activating KRAS detection chip.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2014
Huang Ming-Yii, Liu Hsueh-Chiao, Yen Li-Chen, Chang Jia-Yuan, Huang Jian-Jhang, Wang Jaw-Yuan, Lin Shiu-Ru
Abstract excerpt
The KRAS oncogene was among the first genetic alterations in colorectal cancer (CRC) to be discovered. Moreover, KRAS somatic mutations might be used for predicting the efficiency of anti-epidermal growth factor receptor therapeutic drugs. Because the KRAS mutations are similar in the primary CRC and/or the CRC metastasis, KRAS mutation testing can be performed on both specimen types. The purpose of this study...
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