Article
Evolutionary Transition from Pathogenicity to Commensalism: Global Regulator Mutations Mediate Fitness Gains through Virulence Attenuation.
Molecular biology and evolution - 1 Nov 2015
Jansen Gunther, Crummenerl Lena L, Gilbert Felix, Mohr Timm, Pfefferkorn Roxana, Thänert Robert, Rosenstiel Philip, Schulenburg Hinrich
Abstract excerpt
Symbiotic interactions are indispensable for metazoan function, but their origin and evolution remain elusive. We use a controlled evolution experiment to demonstrate the emergence of novel commensal interactions between Pseudomonas aeruginosa, an initially pathogenic bacterium, and a metazoan ho...
Topics
- Adaptation, Physiological
- Animals
- Bacterial Proteins
- Biological Evolution
- Caenorhabditis elegans
- Evolution, Molecular
- Gene Expression Regulation, Bacterial
- Genetic Association Studies
- Genetic Variation
- Genome, Bacterial
- Host-Pathogen Interactions
- Mutation
- Pseudomonas aeruginosa