Article
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015
Kuo Szu-Yu, Castoreno Adam B, Aldrich Leslie N, Lassen Kara G, Goel Gautam, Dančík Vlado, Kuballa Petric, Latorre Isabel, Conway Kara L, Sarkar Sovan, Maetzel Dorothea, Jaenisch Rudolf, Clemons Paul A, Schreiber Stuart L, Shamji Alykhan F, Xavier Ramnik J
Abstract excerpt
Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here, we describe the discovery of the small-molecule probe BRD5631 that is derived from diversity-oriented synthesis and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.