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Antimicrobial Activity of Fosfomycin-Tobramycin Combination against Pseudomonas aeruginosa Isolates Assessed by Time-Kill Assays and Mutant Prevention Concentrations.

Antimicrobial agents and chemotherapy - 1 Oct 2015

Díez-Aguilar María, Morosini María Isabel, Tedim Ana P, Rodríguez Irene, Aktaş Zerrin, Cantón Rafael

Abstract excerpt

The antibacterial activity of fosfomycin-tobramycin combination was studied by time-kill assay in eight Pseudomonas aeruginosa clinical isolates belonging to the fosfomycin wild-type population (MIC = 64 μg/ml) but with different tobramycin susceptibilities (MIC range, 1 to 64 μg/ml). The mutant prevention concentration (MPC) and mutant selection window (MSW) were determined in five of these strains (tobramycin...

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Identifiers

PMID: 26195514
DOI: 10.1128/AAC.00822-15
PMCID: PMC4576056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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