Article
Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Jan 2015
Muiesan Maria Lorenza, Salvetti Massimo, Paini Anna, Agabiti Rosei Claudia, Rubagotti Giulia, Negrinelli Alessandro, Gregorini Gina, Cancarini Giovanni, Calabresi Laura, Franceschini Guido, Obici Laura, Perlini Stefano, Merlini Giampaolo, Agabiti Rosei Enrico
Abstract excerpt
BACKGROUND: Among hereditary amyloidoses, apolipoprotein A-I (APO A-I) amyloidosis (Leu75Pro) is a rare, autosomal dominant condition in which renal, hepatic, and testicular involvement has been demonstrated. OBJECTIVE: To investigate vascular structural as well as functional alterations. METHODS: In 131 carriers of the amyloidogenic Leu75Pro APO A-I mutation (mean age 52 + 16 years, 56 women) and in 131 subjects...
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