Article
Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy.
International journal of clinical and experimental pathology - 1 Jan 2015
Tang Chao, Guo Jun, Chen Hong, Yao Cheng-Jun, Zhuang Dong-Xiao, Wang Yin, Tang Wei-Jun, Ren Guang, Yao Yu, Wu Jin-Song, Mao Ying, Zhou Liang-Fu
Abstract excerpt
Genetic mutation has served as the biomarkers for the diagnosis and treatment of glioblastoma multiforme (GBM). However, intra-tumor heterogeneity may interfere with personalized treatment strategies based on mutation analysis. This study aimed to characterize somatic mutation profiling of GBM. We collected 33 samples from 7 patients with the primary GBM associated with different Choline (Cho) to...
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