Article
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Atherosclerosis - 1 Sept 2015
Oksala Niku, Pärssinen Jenita, Seppälä Ilkka, Klopp Norman, Illig Thomas, Laaksonen Reijo, Levula Mari, Raitoharju Emma, Kholova Ivana, Sioris Thanos, Kähönen Mika, Lehtimäki Terho, Hytönen Vesa P
Abstract excerpt
BACKGROUND: Kindlins (FERMT) are cytoplasmic proteins required for integrin (ITG) activation, leukocyte transmigration, platelet aggregation and thrombosis. Characterization of kindlins and their association with atherosclerotic plaques in human(s) is lacking. METHODS AND RESULTS: Exploratory microarray (MA) was first performed followed by selective quantitative validation of robustly expressed genes with qRT-PCR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.