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Article

Orphan Nuclear Receptors and the Regulation of Nutrient Metabolism: Understanding Obesity

1 Jun 2012

Abstract excerpt

Nuclear hormone receptors (NRs) are a superfamily of eukaryotic ligand-dependent transcription factors that translate endocrine, metabolic, nutritional, developmental, and pathophysiological signals into gene regulation. Members of the NR superfamily (on the basis of sequence homology) that lack identified natural and/or synthetic ligands are/were classified as "orphan" NRs. These members of the NR superfamily...

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PMID: 22689791
DOI: 10.1152/physiol.00007.2012

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