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Article

Should thiopurine methyltransferase (TPMT) activity be determined before prescribing azathioprine, mercaptopurine, or thioguanine?

Cleveland Clinic journal of medicine - 1 Jul 2015

DiPiero Jennifer, Teng Kathryn, Hicks J Kevin

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Topics

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Share to Azathioprine
Share to TPMT gene
Share to Genotyping Techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

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Source

Identifiers

PMID: 26185939
DOI: 10.3949/ccjm.82a.14106

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Should thiopurine methyltransferase (TPMT) activity be determined before prescribing azathioprine, mercaptopurine, or thioguanine?PMID 26185939Read ↗

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.Semantic proximity Read ↗

Interindividual variability in TPMT enzyme activity: 10 years of experience with thiopurine pharmacogenetics and therapeutic drug monitoring.Semantic proximity Read ↗

Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update.Semantic proximity Read ↗

Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy.Semantic proximity Read ↗

[Individualized therapy with azathioprine or 6-mercaptopurine by monitoring thiopurine methyl-transferase (TPMT) activity].Semantic proximity Read ↗

Thiopurine methyltransferase measurement may not predict azathiopurine-associated non-myelotoxicity.Semantic proximity Read ↗

Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies.Semantic proximity Read ↗

Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come.Semantic proximity Read ↗

Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 UpdateSemantic proximity Read ↗

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tangoSemantic proximity Read ↗

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