Article
Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2016
Lehrer Douglas S, Pato Michele T, Nahhas Ramzi W, Miller Brian R, Malaspina Dolores, Buckley Peter F, Sobell Janet L, Walsh-Messinger Julie, Genomic Psychiatry Cohort Consortium, Pato Carlos N
Abstract excerpt
Advanced paternal age (APA) is a risk factor for schizophrenia (Sz) and bipolar disorder (BP). Putative mechanisms include heritable genetic factors, de novo mutations, and epigenetic mechanisms. Few studies have explored phenotypic features associated with APA. The Genomic Psychiatry Cohort established a clinically characterized repository of genomic samples from subjects with a Sz-BP diagnosis or unaffected...
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