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Article

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.

Bioscience reports - 20 Apr 2015

Haslbeck Veronika, Drazic Adrian, Eckl Julia M, Alte Ferdinand, Helmuth Martin, Popowicz Grzegorz, Schmidt Werner, Braun Frank, Weiwad Matthias, Fischer Gunter, Gemmecker Gerd, Sattler Michael, Striggow Frank, Groll Michael, Richter Klaus

Abstract excerpt

Protein phosphatase 5 (PP5) is an evolutionary conserved serine/threonine phosphatase. Its dephosphorylation activity modulates a diverse set of cellular factors including protein kinases and the microtubule-associated tau protein involved in neurodegenerative disorders. It is auto-regulated by its heat-shock protein (Hsp90)-interacting tetratricopeptide repeat (TPR) domain and its C-terminal α-helix. In the...

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Share to Caenorhabditis elegans Proteins
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Identifiers

PMID: 26182372
DOI: 10.1042/BSR20150042
PMCID: PMC4721540

Genes

TPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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