Article
Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.
Transgenic research - 1 Oct 2015
Scavizzi Ferdinando, Ryder Edward, Newman Stuart, Raspa Marcello, Gleeson Diane, Wardle-Jones Hannah, Montoliu Lluis, Fernandez Almudena, Dessain Marie-Laure, Larrigaldie Vanessa, Khorshidi Zuzana, Vuolteenaho Reetta, Soininen Raija, André Philippe, Jacquot Sylvie, Hong Yi, de Angelis Martin Hrabe, Ramirez-Solis Ramiro, Doe Brendan
Abstract excerpt
With the advent of modern developmental biology and molecular genetics, the scientific community has generated thousands of newly genetically altered strains of laboratory mice with the aim of elucidating gene function. To this end, a large group of Institutions which form the International Mouse Phenotyping Consortium is generating and phenotyping a knockout mouse strain for each of the ~20,000 protein-coding...
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