Article
Parent-progeny sequencing indicates higher mutation rates in heterozygotes.
Nature - 23 Jul 2015
Yang Sihai, Wang Long, Huang Ju, Zhang Xiaohui, Yuan Yang, Chen Jian-Qun, Hurst Laurence D, Tian Dacheng
Abstract excerpt
Mutation rates vary within genomes, but the causes of this remain unclear. As many prior inferences rely on methods that assume an absence of selection, potentially leading to artefactual results, we call mutation events directly using a parent-offspring sequencing strategy focusing on Arabidopsis and using rice and honey bee for replication. Here we show that mutation rates are higher in heterozygotes and in...
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