Article
DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer.
European urology - 1 Jul 2003
Hessels Daphne, Klein Gunnewiek Jacqueline M T, van Oort Inge, Karthaus Herbert F M, van Leenders Geert J L, van Balken Bianca, Kiemeney Lambertus A, Witjes J Alfred, Schalken Jack A
Abstract excerpt
BACKGROUND: DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed. METHODS: The diagnostic potential of DD3(PCA3) was determined by quantitative measurement of DD3(PCA3) transcripts in non-malignant and malignant prostate specimens. Moreover, DD3(PCA3)...
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