Article
CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila.
PloS one - 1 Jan 2015
Ren Guilin R, Hauser Frank, Rewitz Kim F, Kondo Shu, Engelbrecht Alexander F, Didriksen Anders K, Schjøtt Suzanne R, Sembach Frederikke E, Li Shizhong, Søgaard Karen C, Søndergaard Leif, Grimmelikhuijzen Cornelis J P
Abstract excerpt
The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes ccha1 and -2, are produced by endocrine cells in the midgut and by neurons in the brain of Drosophila melanogaster. Here, we used the CRISPR/Cas9 technique to disrupt the ccha1 and -2 genes and identify mutant phenotypes with a focus on ccha-2 mutants. We found that both larval and adult ccha2 mutants showed a significantly reduced food intake as...
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