Article
Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.
Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Oct 2015
Barnett G C, Kerns S L, Noble D J, Dunning A M, West C M L, Burnet N G
Abstract excerpt
There is considerable variation in the level of toxicity patients experience for a given dose of radiotherapy, which is associated with differences in underlying individual normal tissue radiosensitivity. A number of syndromes have a large effect on clinical radiosensitivity, but these are rare. Among non-syndromic patients, variation is less extreme, but equivalent to a ±20% variation in dose. Thus, if...
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