Article
Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials.
Oncotarget - 29 Sept 2015
Subbiah Ishwaria M, Falchook Gerald S, Kaseb Ahmed O, Hess Kenneth R, Tsimberidou Apostolia M, Fu Siqing, Subbiah Vivek, Hong David S, Naing Aung, Piha-Paul Sarina A, Akmal Owais, Janku Filip, Kurzrock Razelle
Abstract excerpt
PURPOSE: Patients with advanced hepatocellular carcinoma (HCC) have limited effective therapeutic options. Given the rapid advanced in drug development and emergence of novel agents, we analyzed the characteristics and outcomes of HCC patients treated on early phase trials with an emphasis on targeted therapies. METHODS: We reviewed the records of consecutive HCC patients evaluated in the Phase I Clinical Trials...
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