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Article

Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.

Molecular immunology - 1 Oct 2015

Bernabéu-Herrero Maria E, Jiménez-Alcázar Miguel, Anter Jaouad, Pinto Sheila, Sánchez Chinchilla Daniel, Garrido Sofía, López-Trascasa Margarita, Rodríguez de Córdoba Santiago, Sánchez-Corral Pilar

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy affecting the renal microvasculature and is associated with complement dysregulation caused by mutations or autoantibodies. Disease penetrance and severity is modulated by inheritance of "risk" polymorphisms in the complement genes MCP, CFH and CFHR1. We describe the prevalence of mutations, the frequency of risk polymorphisms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26163426
DOI: 10.1016/j.molimm.2015.06.021

Genes

CFH
CFHR3
CFHR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.PMID 26163426Read ↗

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