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Article

Metastatic sympathetic paraganglioma in a patient with loss of the SDHC gene.

Familial cancer - 1 Dec 2015

Rich Thereasa, Jackson Michelle, Roman-Gonzalez Alejandro, Shah Komal, Cote Gilbert J, Jimenez Camilo

Abstract excerpt

Mutation of the genes encoding the succinate dehydrogenase (SDH) subunits A, B, C, or D, or the SDHAF2 protein, cause the SDHx-hereditary paraganglioma syndromes. Hereditary susceptibility to metastatic sympathetic pheochromocytomas and paragangliomas is most commonly due to germline mutations in the SDHB gene. Individuals with SDHD mutations occasionally present with metastatic disease, while conversely...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26162468
DOI: 10.1007/s10689-015-9821-0

Genes

SDHC
SDHB
SDHD
SDHAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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