Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix.

Pathology, research and practice - 1 Sept 2015

Hara Kieko, Saito Tsuyoshi, Hayashi Takuo, Yimit Alkam, Takahashi Michiko, Mitani Keiko, Takahashi Makoto, Yao Takashi

Abstract excerpt

Appendiceal mucinous tumors (AMTs) are classified as low-grade appendiceal mucinous neoplasms (LAMNs) or mucinous adenocarcinomas (MACs), although their carcinogenesis is not well understood. As somatic activating mutations of GNAS are considered to be characteristic of LAMNs while TP53 mutations have been shown to be specific to MACs, MACs are unlikely to result from transformation of LAMNs. However, emerging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Mucinous
Share to beta Catenin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Neoplasm Grading

Share to Predictive Value of Tests

Share to Proto-Oncogene Proteins p21(ras)

Share to Telomerase

Source

Identifiers

PMID: 26160192
DOI: 10.1016/j.prp.2015.06.004

Genes

GNAS
KRAS
BRAF
CTNNB1
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix.PMID 26160192Read ↗

Molecular and clinicopathological features of appendiceal mucinous neoplasms.Semantic proximity Read ↗

Mutation profile of high‐grade appendiceal mucinous neoplasmSemantic proximity Read ↗

Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.Semantic proximity Read ↗

Molecular Profiling of Low-Grade Appendiceal Mucinous Neoplasms (LAMN).Semantic proximity Read ↗

Molecular Classification of Appendiceal Adenocarcinoma.Semantic proximity Read ↗

Appendiceal sessile serrated lesions are distinct from their right-sided colonic counterparts and may be precursors for appendiceal mucinous neoplasms.Semantic proximity Read ↗

Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal originSemantic proximity Read ↗

Genomic Landscape of Appendiceal NeoplasmsSemantic proximity Read ↗

Extra-appendiceal low-grade mucinous neoplasm-like lesions: clinicopathologic and molecular characteristics.Semantic proximity Read ↗

GNAS is frequently mutated in both low-grade and high-grade disseminated appendiceal mucinous neoplasms but does not affect survival.Semantic proximity Read ↗

Connecting the dots: Low-grade appendiceal mucinous neoplasms and serrated polyps in the appendix.Semantic proximity Read ↗

Extra-appendiceal mucinous neoplasms: A tumour with clinicopathologic similarities to low- and high-grade appendiceal counterpart.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.