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Appendiceal sessile serrated lesions are distinct from their right-sided colonic counterparts and may be precursors for appendiceal mucinous neoplasms.

Human pathology - 1 Apr 2022

Chezar Ksenia, Minoo Parham

Abstract excerpt

Low-grade appendiceal mucinous neoplasms (LAMNs) can occur concurrently with appendiceal sessile serrated lesions (SSLs). To interrogate relatedness, we performed multigene and immunohistochemical characterizations of paired and unpaired SSLs and LAMNs. We evaluated 62 serrated lesions from 50 appendectomy specimens for hotspot mutations in BRAF, KRAS, and GNAS genes. Cases were subdivided into 3 groups: 20...

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Identifiers

PMID: 35121004
DOI: 10.1016/j.humpath.2022.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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