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Article

Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study.

Human genetics - 1 Jun 2009

Liu Junhao, Sun Kai, Bai Yongyi, Zhang Weili, Wang Xiaojian, Wang Yibo, Wang Hu, Chen Jingzhou, Song Xiaodong, Xin Ying, Liu Zhe, Hui Rutai

Abstract excerpt

Stroke is a common complex trait and does not follow Mendelian pattern of inheritance. Gene-gene or gene-environment interactions may be responsible for the complex trait. How the interactions contribute to stroke is still under research. This study aimed to explore the association between gene-gene interactions and stroke in Chinese in a large case-control study. Nearly 4,000 participants were recruited from...

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Source

Identifiers

PMID: 19373490
DOI: 10.1007/s00439-009-0659-0

Genes

MTHFR
NOTCH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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