Article
Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.
PloS one - 1 Jan 2015
Cremaschi Paolo, Oliverio Matteo, Leva Valentina, Bione Silvia, Carriero Roberta, Mazzucco Giulia, Palamidessi Andrea, Scita Giorgio, Biamonti Giuseppe, Montecucco Alessandra
Abstract excerpt
Moderate DNA damage resulting from metabolic activities or sub-lethal doses of exogenous insults may eventually lead to cancer onset. Human 46BR.1G1 cells bear a mutation in replicative DNA ligase I (LigI) which results in low levels of replication-dependent DNA damage. This replication stress elicits a constitutive phosphorylation of the ataxia telangiectasia mutated (ATM) checkpoint kinase that fails to arrest...
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