Article
BRCA 1/2 gene mutation and gastrointestinal stromal tumours: a potential association.
BMJ case reports - 6 Jul 2015
Waisbren Julie, Uthe Regina, Siziopikou Kalliopi, Kaklamani Virginia
Abstract excerpt
Mutations of the BRCA1/2 genes have been described in association with a number of malignancies including cancers of the breast, ovary, prostate and stomach, but have never been described in relation to gastrointestinal stromal tumours (GIST). We describe a patient with a BRCA2 8642del3insC mutation who developed prostate cancer, breast cancer and GIST. GIST has been shown to be associated with a number of...
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