Article
Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains.
BMC genomics - 4 Jul 2015
Reis-Cunha João Luís, Rodrigues-Luiz Gabriela F, Valdivia Hugo O, Baptista Rodrigo P, Mendes Tiago A O, de Morais Guilherme Loss, Guedes Rafael, Macedo Andrea M, Bern Caryn, Gilman Robert H, Lopez Carlos Talavera, Andersson Björn, Vasconcelos Ana Tereza, Bartholomeu Daniella C
Abstract excerpt
BACKGROUND: Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T. cruzi genome project, is a hybrid with a genome assembled into 41 putative chromosomes. Gene copy number variation (CNV) is well documented as an important mechanism to enhance gene expression and variability in T. cruzi....
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