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Article

Genome plasticity driven by aneuploidy and loss of heterozygosity in Trypanosoma cruzi.

Microbial genomics - 1 Jun 2022

Cruz-Saavedra Lissa, Schwabl Philipp, Vallejo Gustavo A, Carranza Julio C, Muñoz Marina, Patino Luz Helena, Paniz-Mondolfi Alberto, Llewellyn Martin S, Ramírez Juan David

Abstract excerpt

Trypanosoma cruzi the causative agent of Chagas disease shows a marked genetic diversity and divided into at least six Discrete Typing Units (DTUs). High intra genetic variability has been observed in the TcI DTU, the most widely distributed DTU, where patterns of genomic diversity can provide information on ecological and evolutionary processes driving parasite population structure and genome organization....

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Identifiers

PMID: 35748878
DOI: 10.1099/mgen.0.000843
PMCID: PMC9455712

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