Article
Molecular cloning and characterization of presenilin gene in Bombyx mori.
Molecular medicine reports - 1 Oct 2015
Zheng Zeng-Zhang, Chao Meng-Ling, Fan Zong-Biao, Zhao Yi-Jiao, Song Hong-Sheng
Abstract excerpt
Presenilin (PS), the catalytic core of the γ-secretase complex, is considered to be a causative protein of the early‑onset familial form of Alzheimer's disease. Aging is a risk factor for Alzheimer's disease and a number of genetic studies have utilized Bombyx mori (B. mori) as a model, making it possible to use B. mori to investigate Alzheimer's disease. However, the homologous gene of human PS in B. mori has...
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