Article
Inhibitory killer cell immunoglobulin-like receptor (iKIR) mismatches improve survival after T-cell-repleted haploidentical transplantation.
European journal of haematology - 1 May 2016
Bastos-Oreiro Mariana, Anguita Javier, Martínez-Laperche Carolina, Fernández Lucía, Buces Elena, Navarro Almudena, Pascual Cristina, Pérez-Corral Ana, Balsalobre Pascual, Muñoz Cristina, Kwon Mi, Serrano David, Perez-Martinez Antonio, Buño Ismael, Gayoso Jorge, Díez-Martín José Luís
Abstract excerpt
Alloreactivity triggered by interaction between killer cell immunoglobulin-like receptors (KIRs) and natural killer (NK) cells plays a role in the graft-versus-tumor effect after hematopoietic stem cell transplantation (SCT). Our aim in this study was to evaluate this role in the setting of T-cell-repleted haploidentical SCT with postinfusion high-dose cyclophosphamide (PT-Cy). We included 33 patients. Among...
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