Article
Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility.
Genetics and molecular research : GMR - 11 Jun 2015
Aydos S E, Karadağ A, Özkan T, Altınok B, Bunsuz M, Heidargholizadeh S, Aydos K, Sunguroğlu A
Abstract excerpt
Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired repro-ductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug re-sistance1 (MDR1) gene encodes a P-glycoprotein which has a role in the active transport of...
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