Article
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility.
Pharmacological reports : PR - 1 Jan 2000
Droździk Marek, Stefankiewicz Joanna, Kurzawa Rafał, Górnik Wanda, Baczkowski Tomasz, Kurzawski Mateusz
Abstract excerpt
Infertility is a common problem affecting one in six couples, and in 30% of infertile couples, the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, may be a link between genetic and environmental factors contributing to the development of male infertility because pesticides (P-gp substrates) are well established factors of male infertility....
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