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Transduction of Human Islets with Pseudotyped Lentiviral Vectors

1 Feb 2004

Abstract excerpt

Type I diabetes is caused by an autoimmune-mediated elimination of insulin-secreting pancreatic islets. Genetic modification of islets offers a powerful molecular tool for improving our understanding of islet biology. Moreover, efficient genetic engineering of islets could allow for evaluation of new strategies aimed at preventing islet destruction. The present study evaluated the ability of a human...

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PMID: 14975193
DOI: 10.1089/104303404772680010

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