Article
[CLINICAL AND PHARMACOLOGICAL FACTORS INFLUENCING RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH CARDIOVASCULAR DISEASES].
Klinicheskaia meditsina - 1 Jan 2015
Mesitskaia D F, Nikitina Iu M, Kopylov F Iu, Syrkin A L, Aksenova M G, Kirillov M Iu, Dobrovol'skiĭ A V
Abstract excerpt
We analysed clinical and pharmacological factors influencing resistance to clopidogrel in 250 patients with cardiovascular diseases during 18 months. It was shown that the risk ofresistance depends on the form of coronary heart disease, carbohydrate metabolism, the AA genotype of CYP2C19*2 and TBS1 genes. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant...
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