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Article

HbA2: biology, clinical relevance and a possible target for ameliorating sickle cell disease

24 Jun 2015

Abstract excerpt

HbA2 , a tetramer of α- and δ-globin chains, provides a diagnostic clue to the presence of β-thalassaemia trait. This minor haemoglobin, which forms about 2-3% of the total, has no known physiological role, but has the interesting property of preventing polymerization of deoxy-sickle haemoglobin. If it were possible to increase the level of HbA2 sufficiently it could have a benefit in sickle cell disease similar...

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PMID: 26104837
DOI: 10.1111/bjh.13570

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