Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jumonji Histone Demethylase Inhibitor JIB-04 as a Broad-Spectrum Antifungal Agent

13 Jun 2022

Abstract excerpt

Invasive fungal infections are emerging as a global public health problem. The lack of effective antifungal drugs is the bottleneck of clinical antifungal treatment. To identify novel antifungal agents with new mechanisms of action, JIB-04, a Jumonji histone demethylase inhibitor, was identified to possess broad-spectrum antifungal activity by a cell-based screen. Particularly, JIB-04 effectively inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Nail Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35695031
DOI: 10.1021/acsinfecdis.2c00096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jumonji Histone Demethylase Inhibitor JIB-04 as a Broad-Spectrum Antifungal AgentPMID 35695031Read ↗

Histone Deacetylases and Their Inhibition in Candida SpeciesSemantic proximity Read ↗

H3K4 Methylation and Demethylation in Fungal Pathogens: The Epigenetic Toolbox for Survival and Adaptation in the HostSemantic proximity Read ↗

Epigenetic Strategies to Discover Novel Fungal Secondary MetabolitesSemantic proximity Read ↗

Histone Acetylation/Deacetylation in Candida Albicans and their Potential as Antifungal TargetsSemantic proximity Read ↗

Brilacidin, a novel antifungal agent against <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida aurisSemantic proximity Read ↗

Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida aurisSemantic proximity Read ↗

Antifungal therapeutic potential of <i>Candida albicans</i> Fun30: screening and validation of novel inhibitors against <i>Candida albicans</i>Semantic proximity Read ↗

Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literatureSemantic proximity Read ↗

Effects of Hst3p inhibition in Candida albicans: a genome-wide H3K56 acetylation analysisSemantic proximity Read ↗

HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulenceSemantic proximity Read ↗

Hinokitiol alters Gene Expression in <i>Aspergillus fumigatus</i> , protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil InfiltrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.