Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis.

doi:10.1371/journal.pone.0112669

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Article

Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis.

PloS one - 1 Jan 2014

Santos Julliana Ribeiro Alves, Holanda Rodrigo Assunção, Frases Susana, Bravim Mayara, Araujo Glauber de S, Santos Patrícia Campi, Costa Marliete Carvalho, Ribeiro Maira Juliana Andrade, Ferreira Gabriella Freitas, Baltazar Ludmila Matos, Miranda Aline Silva, Oliveira Danilo Bretas, Santos Carolina Maria Araújo, Fontes Alide Caroline Lima, Gouveia Ludmila Ferreira, Resende-Stoianoff Maria Aparecida, Abrahão Jonatas Santos, Teixeira Antônio Lúcio, Paixão Tatiane Alves, Souza Danielle G, Santos Daniel Assis

Abstract excerpt

Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for treatment of cryptococcosis, but the emergence of less susceptible strains to this azole is a global problem and also the data regarding fluconazole-resistant cryptococcosis are scarce. We evaluate the influence of fluconazole on murine cryptococcosis and whether this azole alters the polysaccharide (PS) from cryptococcal cells....

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PMID: 25392951
DOI: 10.1371/journal.pone.0112669
PMCID: PMC4231059

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