Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

doi:10.1534/genetics.115.178624

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Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Genetics - 1 Aug 2015

Lapham Kyle, Kvale Mark N, Lin Jue, Connell Sheryl, Croen Lisa A, Dispensa Brad P, Fang Lynn, Hesselson Stephanie, Hoffmann Thomas J, Iribarren Carlos, Jorgenson Eric, Kushi Lawrence H, Ludwig Dana, Matsuguchi Tetsuya, McGuire William B, Miles Sunita, Quesenberry Charles P, Rowell Sarah, Sadler Marianne, Sakoda Lori C, Smethurst David, Somkin Carol P, Van Den Eeden Stephen K, Walter Lawrence, Whitmer Rachel A, Kwok Pui-Yan, Risch Neil, Schaefer Catherine, Blackburn Elizabeth H

Abstract excerpt

The Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort includes DNA specimens extracted from saliva samples of 110,266 individuals. Because of its relationship to aging, telomere length measurement was considered an important biomarker to develop on these subjects. To assay relative telomere length (TL) on this large...

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PMID: 26092717
DOI: 10.1534/genetics.115.178624
PMCID: PMC4574243

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