Article
Endocannabinoids drive the acquisition of an alternative phenotype in microglia.
Brain, behavior, and immunity - 1 Oct 2015
Mecha M, Feliú A, Carrillo-Salinas F J, Rueda-Zubiaurre A, Ortega-Gutiérrez S, de Sola R García, Guaza C
Abstract excerpt
The ability of microglia to acquire diverse states of activation, or phenotypes, reflects different features that are determinant for their contribution to homeostasis in the adult CNS, and their activity in neuroinflammation, repair or immunomodulation. Despite the widely reported immunomodulatory effects of cannabinoids in both the peripheral immune system and the CNS, less is known about how the...
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