Article
A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2015
Amy Maïté, Staehlin Oliver, René Frédérique, Blasco Hélène, Marouillat Sylviane, Daoud Hussein, Vourc'h Patrick, Gordon Paul H, Camu William, Corcia Philippe, Loeffler Jean-Philippe, Palkovits Miklós, Sommer Wolfgang H, Andres Christian R
Abstract excerpt
Amyotrophic lateral sclerosis is sporadic (SALS) in 90% of cases and has complex environmental and genetic influences. Nogo protein inhibits neurite outgrowth and is overexpressed in muscle in ALS. Our aims were to study the reticulon 4 receptor gene RTN4R which encodes Nogo 1 receptor (NgR1) in SALS, to test if the variants were associated with variable expression of the gene and whether NgR1 protein expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.