Whole-genome analysis of sporadic amyotrophic lateral sclerosis.

doi:10.1056/NEJMoa070174

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Article

Whole-genome analysis of sporadic amyotrophic lateral sclerosis.

The New England journal of medicine - 23 Aug 2007

Dunckley Travis, Huentelman Matthew J, Craig David W, Pearson John V, Szelinger Szabolcs, Joshipura Keta, Halperin Rebecca F, Stamper Chelsea, Jensen Kendall R, Letizia David, Hesterlee Sharon E, Pestronk Alan, Levine Todd, Bertorini Tulio, Graves Michael C, Mozaffar Tahseen, Jackson Carlayne E, Bosch Peter, McVey April, Dick Arthur, Barohn Richard, Lomen-Hoerth Catherine, Rosenfeld Jeffrey, O'connor Daniel T, Zhang Kuixing, Crook Richard, Ryberg Henrik, Hutton Michael, Katz Jonathan, Simpson Ericka P, Mitsumoto Hiroshi, Bowser Robert, Miller Robert G, Appel Stanley H, Stephan Dietrich A

Abstract excerpt

BACKGROUND: Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes. METHODS: We performed a genomewide association analysis using 766,955 single-nucleotide polymorphisms (SNPs) found in 386 white patients with sporadic ALS and 542 neurologically normal white controls (the...

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PMID: 17671248
DOI: 10.1056/NEJMoa070174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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