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High-resolution characterization of sequence signatures due to non-random cleavage of cell-free DNA

16 Jun 2015

Abstract excerpt

BACKGROUND: High-throughput sequencing of cell-free DNA fragments found in human plasma has been used to non-invasively detect fetal aneuploidy, monitor organ transplants and investigate tumor DNA. However, many biological properties of this extracellular genetic material remain unknown. Research that further characterizes circulating DNA could substantially increase its diagnostic value by allowing the...

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PMID: 26081108
DOI: 10.1186/s12920-015-0107-z

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